{"product_id":"gemidipine-tm-50-tab-15s","title":"Gemidipine TM 50 Tablet","description":"\u003cb\u003eAbout\u003c\/b\u003e\u003ci\u003eGemidipine TM 50 Tablet is a combination of Cilnidipine 10mg and Telmisartan 80mg used to treat hypertension (high blood pressure) and provide comprehensive cardiovascular and renal protection in patients requiring higher ARB dose.\u003c\/i\u003e\u003cb\u003eUsage Instructions:\u003c\/b\u003e Take once daily at the same time, with or without food. Swallow whole with water; do not crush or chew. Continue even if feeling well. Do not stop suddenly without medical advice. Take consistently at the same time daily.\u003cb\u003eBenefits:\u003c\/b\u003e Provides intensive blood pressure control with dual mechanism, significantly reduces risk of stroke, heart attack, cardiovascular death, and hospitalization for heart failure, provides superior BP control compared to lower doses, provides renal protection and reduces proteinuria (especially important in diabetic nephropathy), improves endothelial function and reduces arterial stiffness, reduces left ventricular hypertrophy, provides 24-hour BP control with once-daily dosing, suitable for patients with diabetes, chronic kidney disease, metabolic syndrome, or very high cardiovascular risk.\u003cb\u003eHow it Works:\u003c\/b\u003e Cilnidipine selectively blocks L-type and N-type voltage-gated calcium channels in vascular smooth muscle cells and sympathetic nerve terminals, causing vasodilation, reducing peripheral vascular resistance, and inhibiting norepinephrine release. Telmisartan is an angiotensin II receptor blocker (ARB) that selectively antagonizes AT1 receptors, blocking vasoconstriction, aldosterone secretion, and sympathetic activation caused by angiotensin II. Combined action provides synergistic blood pressure reduction through complementary pathways (calcium channel blockade + RAAS inhibition), with enhanced renal protection (reduced intraglomerular pressure, reduced proteinuria), cardiovascular protection (reduced afterload, improved endothelial function, plaque stabilization), and metabolic benefits (improved insulin sensitivity with telmisartan's PPAR-γ modulation).\u003cb\u003eSide Effects:\u003c\/b\u003e Common: dizziness, headache, fatigue, hypotension (especially initially or in volume-depleted patients), peripheral edema (ankle\/foot swelling; less with cilnidipine than other CCBs), constipation, nausea, dyspepsia, back pain, upper respiratory tract infection, hyperkalemia. Serious: severe hypotension (SBP \u0026lt;90 mmHg), acute kidney injury (especially in bilateral renal artery stenosis or severe heart failure), severe hyperkalemia (K+ \u0026gt;5.5 mEq\/L), angioedema (rare with ARBs but potentially life-threatening), severe allergic reactions (anaphylaxis, SJS\/TEN), hepatotoxicity, rhabdomyolysis (rare).\u003cb\u003eSafety Advice:\u003c\/b\u003e Contraindicated in pregnancy (ARBs cause fetal renal malformations, oligohydramnios, and death), severe renal impairment (eGFR \u0026lt;30 mL\/min\/1.73m²), bilateral renal artery stenosis, or hypersensitivity to cilnidipine, telmisartan, or sulfonamides. Use caution in diabetes (may worsen glycemic control initially), hepatic impairment, pre-existing hyperkalemia, or volume depletion. Monitor blood pressure, renal function (serum creatinine, eGFR), and electrolytes (potassium, sodium) at baseline and within 1-2 weeks after initiation or dose increase. May increase serum potassium; avoid potassium supplements, potassium-sparing diuretics (spironolactone, eplerenone, amiloride), or salt substitutes containing potassium unless specifically prescribed and monitored. Inform doctor of dizziness, syncope, muscle weakness\/cramps, irregular heartbeat, decreased urination, or signs of angioedema (swelling of face, lips, tongue, throat, difficulty breathing). Maintain adequate fluid intake. Do not discontinue abruptly.\u003cb\u003eStorage:\u003c\/b\u003e Store below 25°C in a dry place. Protect from light and moisture. Keep in original packaging. Keep out of reach of children. Do not remove from blister until ready to use.","brand":"ETABX","offers":[{"title":"Default Title","offer_id":48303100788873,"sku":"185781","price":275.5,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0709\/5576\/1801\/files\/EtabxDefaultimage_40ac5e2d-3e7b-4d8f-a9c7-16b6d028668a.jpg?v=1776753136","url":"https:\/\/etabx.com\/products\/gemidipine-tm-50-tab-15s","provider":"ETABX","version":"1.0","type":"link"}