{"product_id":"sitason-gm-2-500-tab-10s","title":"Sitason GM 2\/500 Tablet","description":"\u003cb\u003eAbout\u003c\/b\u003e\u003ci\u003eSitason GM 2\/500 Tablet is a triple combination of Sitagliptin 50mg, Glimepiride 2mg, and Metformin 500mg used to improve blood sugar control in adults with type 2 diabetes mellitus when dual therapy is inadequate.\u003c\/i\u003e\u003cb\u003eUsage Instructions:\u003c\/b\u003e Take once or twice daily with meals, or as directed by your physician. Swallow whole with water; do not crush or chew. Take consistently at the same time(s) daily with food to minimize GI upset. Individualize dose based on glycemic response and tolerability.\u003cb\u003eBenefits:\u003c\/b\u003e Provides comprehensive glycemic control with three complementary mechanisms, significantly lowers fasting and post-meal blood glucose, reduces HbA1c by 2-3.5%, enhances glucose-dependent insulin secretion (sitagliptin), stimulates insulin release (glimepiride), improves insulin sensitivity and reduces hepatic glucose output (metformin), delays or prevents diabetes complications (retinopathy, nephropathy, neuropathy).\u003cb\u003eHow it Works:\u003c\/b\u003e Sitagliptin inhibits dipeptidyl peptidase-4 (DPP-4), prolonging activity of incretin hormones (GLP-1, GIP) which stimulate glucose-dependent insulin release from beta cells and suppress glucagon secretion from alpha cells. Glimepiride binds to SUR1 receptor on beta-cell K+ channels, causing depolarization and insulin release. Metformin activates AMPK, inhibiting gluconeogenesis and enhancing peripheral glucose uptake. Triple action addresses insulin resistance, beta-cell dysfunction, and excessive hepatic glucose production.\u003cb\u003eSide Effects:\u003c\/b\u003e Common: hypoglycemia (especially with missed meals or excessive exercise), gastrointestinal upset (nausea, diarrhea, abdominal pain, metallic taste), headache, dizziness, upper respiratory infection, weight gain (glimepiride), vitamin B12 deficiency with long-term use. Serious: severe\/prolonged hypoglycemia, lactic acidosis (very rare), acute pancreatitis, severe allergic reactions (angioedema, SJS), hepatotoxicity, hemolysis in G6PD deficiency.\u003cb\u003eSafety Advice:\u003c\/b\u003e Educate on hypoglycemia recognition and management (carry fast-acting carbohydrates). Monitor blood glucose and HbA1c regularly. Assess renal function before initiation and periodically (eGFR). Avoid in eGFR \u0026lt;30 mL\/min. Limit alcohol intake. Supplement vitamin B12 if deficient. Contraindicated in type 1 diabetes, DKA, severe renal\/hepatic impairment, or acute metabolic stress (sepsis, dehydration). Temporarily discontinue before iodinated contrast procedures and major surgery. Report severe abdominal pain, persistent nausea\/vomiting, or signs of hypoglycemia.\u003cb\u003eStorage:\u003c\/b\u003e Store below 25°C. Protect from light, heat, and moisture. Keep in original blister pack. Keep out of reach of children. Do not use if packaging is compromised.","brand":"ETABX","offers":[{"title":"Default Title","offer_id":48302991605897,"sku":"185891","price":62.7,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0709\/5576\/1801\/files\/EtabxDefaultimage_40ac5e2d-3e7b-4d8f-a9c7-16b6d028668a.jpg?v=1776753136","url":"https:\/\/etabx.com\/products\/sitason-gm-2-500-tab-10s","provider":"ETABX","version":"1.0","type":"link"}