Humiglim M2 Sita 500/50 Tablet

AboutHumiglim M2 Sita 500/50 Tablet is a combination of Sitagliptin 50mg and Metformin 500mg used to improve blood sugar control in adults with type 2 diabetes mellitus inadequately controlled on metformin monotherapy.Usage Instructions: Take twice daily with meals, or as prescribed by your doctor. Swallow whole with water; do not crush or chew. Take consistently at the same time(s) daily with food to minimize GI upset. Individualize dose based on glycemic response and tolerability.Benefits: Improves glycemic control in type 2 diabetes, significantly lowers fasting and post-meal blood glucose, reduces HbA1c by 1.5-2.5%, enhances glucose-dependent insulin secretion (sitagliptin), improves insulin sensitivity and reduces hepatic glucose output (metformin), low risk of hypoglycemia, weight neutral or modest weight loss, delays or prevents diabetes complications (retinopathy, nephropathy, neuropathy).How it Works: Sitagliptin inhibits dipeptidyl peptidase-4 (DPP-4), prolonging activity of incretin hormones (GLP-1, GIP) which stimulate glucose-dependent insulin release from beta cells and suppress glucagon secretion from alpha cells. Metformin activates AMP-activated protein kinase (AMPK), inhibiting gluconeogenesis and enhancing peripheral glucose uptake. Combined action addresses insulin resistance and beta-cell dysfunction.Side Effects: Common: gastrointestinal upset (nausea, diarrhea, abdominal pain, metallic taste), headache, dizziness, upper respiratory infection, nasopharyngitis. Serious: lactic acidosis (very rare), acute pancreatitis, severe allergic reactions (angioedema, SJS), hepatotoxicity.Safety Advice: Educate on hypoglycemia recognition (though low risk). Monitor blood glucose and HbA1c regularly. Assess renal function before initiation and periodically (eGFR). Avoid in eGFR <30 mL/min. Limit alcohol intake. Supplement vitamin B12 if deficient. Contraindicated in type 1 diabetes, DKA, severe renal/hepatic impairment, or acute metabolic stress. Temporarily discontinue before iodinated contrast procedures and major surgery. Report severe abdominal pain, persistent nausea/vomiting, or signs of allergic reaction.Storage: Store below 25°C. Protect from light, heat, and moisture. Keep in original blister pack. Keep out of reach of children. Do not use if packaging is compromised.